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Migraine Treatment


What Is a Migraine?

Migraines—commonly referred to as migraine headaches—affect 12% of the U.S. population.

Migraines are most common among pre-menopausal women, but they can also affect men, children, as well as post-menopausal women.

Most people who experience migraines have them one to four times per month, but they can occur more frequently. Diagnosis is based primarily on clinical signs and symptoms, and if there is any uncertainty, you may need to have diagnostic tests to confirm your condition.

There are a number of migraine triggers, and it can be particularly helpful to identify and avoid the situations that provoke your migraines. If you are prone to migraines, preventative treatment can help reduce the frequency and severity. There are many treatment options that can help to alleviate your symptoms if and when your migraines do occur.

Biochemical Reaction

Fear is a natural emotion and a survival mechanism. When we confront a perceived threat, our bodies respond in specific ways. Physical reactions to fear include sweating, increased heart rate, and high adrenaline levels that make us extremely alert.

This physical response is also known as the “fight or flight” response, with which your body prepares itself to either enter combat or run away. This biochemical reaction is likely an evolutionary development. It’s an automatic response that is crucial to our survival.

Migraine Symptoms

A headache is the most common migraine symptom, but you may experience other symptoms as well. Sometimes, you can have a migraine without any headaches at all. Often, a migraine is preceded by a prodrome, which can begin up to three days before a migraine reaches its peak. If your migraines are typically preceded by a prodromal phase, you will begin to recognize the signs of an impending episode.

There are four sequential stages of a migraine—prodrome, aura, headache, and postdrome—and you may experience between one and four of them with each of your migraine attacks.


You may feel your migraine headaches all over your head, on one side, at the front, or at the back of your head. The headaches that are part of a migraine attack are often described as severe, throbbing, pounding, aching, or persistent. They typically worsen when you move your head, particularly if you lower your head or turn it upside down (as with some exercises)

Other common migraine symptoms include:

  • Neck pain
  • Shoulder pain 
  • Photophobia (sensitivity or intolerance of lights)
  • Phonophobia (sensitivity or intolerance of sounds)
  • Fatigue
  • Dizziness 
  • Irritability
  • Moodiness
  • Nausea
  • Vomiting (especially in children)
  • Loss of appetite 
  • Trouble concentrating 
  • Tingling of the fingers or hands 
  • Ringing in the ears 
  • Visual changes (such as seeing bright lights, spots, or squiggly lines)
  • A sense of feeling detached from your surroundings 
  • Alice in Wonderland syndrome (also known as Todd’s syndrome—a condition in which you feel that your body or your surroundings are out of proportion)

Migraine Aura

A migraine aura typically begins a few hours before a migraine reaches its peak. Generally, a migraine aura is characterized by symptoms such as visual changes, weakness, or numbness.

It can be difficult to distinguish an aura from a stroke, so you should get medical attention if you develop these symptoms without having a diagnosis of migraine with aura.


There are many migraine triggers, but it is not clear why some people are prone to migraines and exactly what causes them to occur.

There are several risk factors that make you more prone to developing migraines. Women are more likely to experience migraines than men, and you are more likely to have migraines if you have a family history of the condition. Depression increases the risk of having migraines, although most people who have migraines do not also have depression.

If you are prone to migraines, you are more likely to experience them in response to certain triggers. The most common migraine triggers include:

  • Hormonal changes (such as those corresponding to menstrual cycle)
  • Lack of sleep or jet lag 
  • Stress
  • Bright lights 
  • Noxious or chemical odors 
  • Caffeine withdrawal 
  • Illness (such as iron deficiency anemia)
  • Infection
  • Hunger 
  • Medications 
  • Anxiety

The exact cause of migraines is unclear. They seem to be related to several physiologic alterations in the brain, which include vasodilation (widening) of the blood vessels in the brain, alterations of neurotransmitters in the brain, or changes in the electrical rhythm of brain activity.

All of these changes have been documented with migraines, but it is not clear which occurs first and why or how a migraine begins.


The headaches and other symptoms that accompany a migraine can be concerning because they overlap with many of the common signs of serious neurological diseases.

If you have new headaches, severe headaches, or neurological symptoms, your doctor will evaluate you to determine whether you have migraines or another condition.

Migraines can produce neurological symptoms, such as tingling sensations and visual changes, so it is important to be sure that you aren’t experiencing a neurological condition such as a transient ischemic attack (TIA) or multiple sclerosis (MS).

Your medical history is a particularly important part of your diagnosis. If your symptoms correspond with your menstrual cycle, if recognizable triggers provoke them, or if you don’t have any symptoms in between the events, this is a strong sign that migraines could be the cause.

Your doctor will also do a thorough physical examination, including a neurological examination, to see if you have any physical deficits. If there is any uncertainty about your condition, or if you have risk factors of stroke or other neurological illness, your doctor may run some tests to rule out a medical illness as the cause of your symptoms.

Diagnostic Tests

There are a variety of diagnostic tests that your doctor may perform to discern a diagnosis of migraines.


Blood tests: A complete blood count (CBC), electrolyte levels, and thyroid tests are among the blood tests that can detect medical conditions that most commonly manifest as severe headaches or other typical migraine symptoms.

For example, thyroid disease and anemia (decreased red blood cell function) can cause fatigue and headaches.


Brain imaging: Some of the neurological symptoms that can occur with migraines may also be manifestations of stroke, TIA, MS, a brain tumor, a brain aneurysm, upper spine problems, or any other neurological condition. Many neurological conditions can be detected by brain computerized tomography (CT) or magnetic resonance imaging (MRI).


Lumbar puncture: If your doctor is concerned that you could have brain inflammation, MS, meningitis (an infection of the protective layer around the brain), or encephalitis (a brain infection), you may need to have a lumbar puncture, also called a spinal tap.

This is a minimally invasive test in which your doctor places a small needle in your back (below the level of your spine) to obtain a sample of spinal fluid, which is sent for laboratory analysis. This test is mildly uncomfortable, but it is safe, and the discomfort resolves after a few minutes.


Electrocardiograph (EKG) or Echocardiogram: Heart problems can cause dizziness and low energy, and may also cause headaches. An abnormal heart rhythm can be detected with an EKG.

A patent foramen ovale (PFO)—which is a defective opening in the heart tissue—has been associated with migraines, although the link is controversial. This condition can be diagnosed with an echocardiogram and can be surgically repaired. However, PFO closure has been found in clinical trials not to be effective for the treatment of migraines.


There are a number of effective migraine treatments that are used for acute migraine attacks, including over-the-counter (OTC) and prescription medications. In severe cases, medication injections have also been effective. Some people experience migraine symptom improvement with complementary and alternative treatments (CAM), such as eating ginger or inhaling lavender oil.

It is usually a good idea to try CAM treatments or OTC medications first. If these don’t work, you can try advancing to the stronger prescription treatments only if the complementary and alternative medicine (CAM) or OTC options don’t effectively reduce your migraine symptoms, or if you can’t tolerate the side effects.


Complementary and Alternative Medicine (CAM)

The butterbur plant seems to be effective in some clinical trial results. Further CAM treatment options that may be worth investigating include feverfew (a plant), magnesium, coenzyme 10Q, and vitamin B2 (riboflavin).

Be sure to discuss these CAM choices with your doctor to see if one (or a combination) may work for you.


Over-the-Counter (OTC)

OTC treatments include non-steroidal anti-inflammatories (NSAIDs), aspirin, naproxen, and ibuprofen, as well as acetaminophen—which is not an NSAID.



Prevention is really the cornerstone of managing migraines, and you are in primary control of sticking with your own migraine prevention strategy.

You are the best judge of how well something works and whether you experience any side effects.

You and your doctor will have to decide which preventative option is best for you based on your own health risks, side effects, and how well the preventative therapy works for you.

There are several preventative medications that can help reduce the frequency and severity of migraine attacks.


Avoid Triggers

It is especially important that you identify and avoid your migraine triggers. Pay special attention to situations and events that occur in your life before you have a migraine. Common triggers include sleep deprivation, stress, and eating foods that contain additives such as nitrates.

Lifestyle strategies are even more important than medication when it comes to migraine prevention.


You may need to adjust your lifestyle and daily activities when you have a migraine. Depending on the frequency and severity of your episodes, you might need to take on less demanding tasks or get extra rest while you recover. Most people with migraines learn to effectively plan work and other tasks well in advance to avoid falling behind if a migraine hits.

It is also important for you to decide when you should take your abortive therapy—some people notice that it works best just when an aura is starting, while some feel that the effects wear off too soon if they take strong prescription medications before the migraine symptoms begin. Optimally timing your therapy is an important part of coping.



If you feel depressed before or during your migraines, it is helpful for you to be aware of this tendency and to remember that the depression will wear off after your migraine resolves.

However, if you experience prolonged periods of depression, you should talk to your doctor. Medical treatment or counseling for your mood may be necessary.



Another important aspect of coping with migraines includes communication. You might find that telling close friends and family when you have a migraine can help you avoid appearing rude or antisocial if you just want to take it easy.

Sharing and communicating with coworkers and colleagues is very dependent on your situation. While many colleagues may be understanding or empathetic, some may try to make life difficult for you if you admit to certain weaknesses on the job. You need to carefully weigh the advantages and disadvantages of sharing details about your migraines in your own work setting, and make the best decision for you.


Authors: Heidi Moawad, MD

Citation: verywellmind.com

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